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Observe Closely (1)pentobarbital will reduce the extent or impact of buprenorphine subdermal implant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Observe people now on buprenorphine subdermal implant who require recently-initiated cure with CYP3A4 inducer for indications and symptoms of withdrawal. If you

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